Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia?
A Steinborn, GM Haensch, K Mahnke, E Schmitt… - Clinical …, 2008 - Elsevier
Regulatory T cells (CD4+ CD25+ FoxP3+-Treg cells) are important regulators of tolerance
induction during pregnancy. We now found that the number of CD4+ CD25+ FoxP3+-Treg
cells decreases during normal course of pregnancy and even more so in women affected by
preeclampsia. The functional activity of these CD4+ CD25+-Treg cells was significantly
reduced in comparison to those of healthy pregnants. Further analysis revealed two Treg
subsets that differed with regard to the FoxP3 and CD25 expression. The percentage of …
induction during pregnancy. We now found that the number of CD4+ CD25+ FoxP3+-Treg
cells decreases during normal course of pregnancy and even more so in women affected by
preeclampsia. The functional activity of these CD4+ CD25+-Treg cells was significantly
reduced in comparison to those of healthy pregnants. Further analysis revealed two Treg
subsets that differed with regard to the FoxP3 and CD25 expression. The percentage of …
