MicroRNAs: new players in IBD
Gut, 2015•gut.bmj.com
MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as
post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the
pathogenesis of many common diseases, including IBDs. This review aims to outline the
history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and
regulation of the innate and adaptive immune system is discussed, with a particular focus on
mechanisms pertinent to IBD and the potential translational applications.
post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the
pathogenesis of many common diseases, including IBDs. This review aims to outline the
history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and
regulation of the innate and adaptive immune system is discussed, with a particular focus on
mechanisms pertinent to IBD and the potential translational applications.
MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.
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