Lipopolysaccharide (LPS) induced pulmonary neutrophil recruitment and platelet activation is mediated via the P2Y1 and P2Y14 receptors in mice
RT Amison, S Arnold, BG O'shaughnessy… - Pulmonary …, 2017 - Elsevier
Platelet activation occurs during host defence and in various inflammatory disorders. In
animal models of infection and inflammation, experimental depletion of platelets leads to
significantly reduced leukocyte recruitment and impaired clearance of pathogens from the
lung. It is now appreciated that purinergic receptor activation is required for leukocyte
activation, motility and adhesion, and platelet interactions with leukocytes can be modulated
by purinergic stimulation of platelets. Here, we have investigated the role of platelet P2Y 1 …
animal models of infection and inflammation, experimental depletion of platelets leads to
significantly reduced leukocyte recruitment and impaired clearance of pathogens from the
lung. It is now appreciated that purinergic receptor activation is required for leukocyte
activation, motility and adhesion, and platelet interactions with leukocytes can be modulated
by purinergic stimulation of platelets. Here, we have investigated the role of platelet P2Y 1 …
